How Do The Diet Drugs Lorcaserin And Phentermine-Topiramate Help People Lose Weight?
Lorcaserin is a serotonin receptor agonist that selectively stimulates 5-HT2C receptors. Activation of these receptors reduces food intake and body weight. The FDA initially approved the drug to treat obesity in 2012.
Phentermine-topiramate is a combination drug containing phentermine, an appetite suppressant, and topiramate, a weight-loss medication. The FDA approved it in 2015 for the treatment of obesity. Phentermine-topiramate works by reducing appetite and calorie intake and by increasing energy expenditure.
Both lorcaserin and phentermine-topiramate are effective at promoting weight loss. In clinical trials, lorcaserin led to a 5-10% or more weight loss in 33%-55% of overweight or obese adults. The number for phentermine-topiramate was very similar.
Taking phentermine and topiramate separately:
Topiramate:
“Since topiramate is a CNS depressant, additive effects can be anticipated when it is used concomitantly with alcohol or other CNS-depressant drugs. Topiramate may exacerbate metabolic acidosis.
The risk of skeletal hyperostosis and hypercalciuria increases with the increased levels of serum calcium seen in chronic alcoholics following a reduction in ethanol intake secondary to the initiation of topiramate treatment.”
Phentermine:
“The potential for additive pharmacodynamic effects of phentermine and alcohol exists. Concomitant use of CNS stimulants, such as phentermine and alcohol, may have adverse cardiovascular effects. The use of phentermine with other sympathomimetic agents is not recommended.”
So, it is best to avoid taking these two medications together. If you are currently accepting both drugs, it is essential to speak with your doctor to discuss the potential risks and safely discontinue either medication.
If you are thinking about starting either phentermine or topiramate, be sure to talk to your doctor first to see if they are safe for you to take. Some people may be more at risk for side effects than others, and your doctor can help you weigh the risks and benefits of each medication.
When it comes to weight loss, there is no one-size-fits-all approach. What works for some people may not work for others. If you are struggling to lose weight, it is essential to speak with your doctor to find a safe and effective way to reach your goals.
Other medications or treatments may be available that can help you lose weight healthily and securely. Remember, it is always important to speak with your doctor before starting any new medication or treatment.
How much weight can you lose on phen:
“On average, people taking phentermine can lose 3-5 pounds a week. However, people can lose more or less weight depending on how much they eat and how active they are.”
So, on average, people can lose 3-5 pounds per week while taking phentermine. It is important to remember that everyone is different, and you may lose more or less weight than this.
Additionally, it is essential to be active and eat a healthy diet to help promote weight loss. If you are struggling to lose weight, speaking with your doctor about starting phentermine may be a good option for you.
Phentermine vs phendimetrazine:
“Phentermine and phendimetrazine are both sympathomimetic amines. They work by stimulating the central nervous system (CNS), which causes the body to release more norepinephrine. This increases heart rate and blood pressure and makes the body burn more calories.”
So, phentermine and phendimetrazine both work by stimulating the CNS. This causes the body to release more norepinephrine, which increases heart rate and blood pressure and makes the body burn more calories. Additionally, phentermine is a shorter-acting medication than phendimetrazine.
Both phentermine and phendimetrazine are effective at promoting weight loss. In clinical trials, phentermine led to a weight loss of 5-8 pounds, whereas phendimetrazine led to 7-10 pounds. Both medications had similar side effects: increased heart rate and blood pressure, dry mouth, constipation, decreased appetite, and insomnia.